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| Management number | 204569865 | Release Date | 2025/10/14 | List Price | $24.61 | Model Number | 204569865 | ||
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| Category | |||||||||
Simparica Trio Chewable Tablets for Dogs 22.1-44.0 lbs offer comprehensive, all-in-one protection against fleas, ticks, heartworms, roundworms, and hookworms. Designed for medium-sized dogs, this once-monthly, liver-flavored chew makes parasite prevention easy and effective.
Manufactured by Zoetis, Simparica Trio is an FDA-approved, vet-recommended treatment that starts working within hours and provides 30 days of continuous protection. With just one chew, your dog gets fast-acting, broad-spectrum defense against harmful parasites—no need for multiple medications.
Simparica Trio is available in different dosage strengths to ensure optimal protection for dogs of all sizes. Find the perfect dose for your furry friend:
✅ Simparica Trio Chewable Tablets for Puppies 2.8-5.5 lbs
✅ Simparica Trio Chewable Tablets for Dogs 5.6-11.0 lbs
✅ Simparica Trio Chewable Tablets for Dogs 11.1-22.0 lbs
✅ Simparica Trio Chewable Tablets for Dogs 44.1-88.0 lbs
✅ Simparica Trio Chewable Tablets for Dogs 88.1-132.0 lbs
Ensure your dog gets the right dosage for their size and weight to receive full-spectrum parasite protection. 🐶💙
✔ 3-in-1 Parasite Defense – Prevents heartworm disease, eliminates fleas & ticks, and treats roundworms & hookworms.
✔ Fast & Effective – Kills fleas in 4 hours and ticks in 8 hours while ensuring month-long protection.
✔ Veterinarian-Recommended & FDA-Approved – Safe and trusted by vets for comprehensive parasite prevention.
✔ Tasty & Easy to Administer – Liver-flavored chewable eliminates the need for messy topical treatments.
✔ Proven Performance – Clinically tested for high efficacy against fleas, ticks, and intestinal parasites.
| Parasite | Effectiveness |
|---|---|
| Fleas | 100% within 8 hours |
| Ticks (5 species) | 98.9% |
| Roundworms | 99.2% |
| Hookworms | 94% |
Simparica Trio combines three active ingredients to deliver full-body parasite protection:
With one chew per month, Simparica Trio provides continuous, head-to-tail parasite defense for your dog.
| Dog Weight (lbs) | Sarolaner (mg) | Moxidectin (mg) | Pyrantel (mg) | Tablets Per Month |
|---|---|---|---|---|
| 22.1 – 44.0 lbs | 24 mg | 0.48 mg | 100 mg | 1 tablet |
For broader parasite protection, some pet owners opt for Simparica Trio 22.1-44 lbs 6 Month Supply, which protects against:
| Feature | Simparica | Simparica Trio |
|---|---|---|
| Kills Fleas & Ticks | ✅ Yes | ✅ Yes |
| Prevents Heartworm Disease | ❌ No | ✅ Yes |
| Treats Intestinal Worms (Roundworms & Hookworms) | ❌ No | ✅ Yes |
| Dosing Schedule | Monthly | Monthly |
If your dog also needs heartworm prevention, consider upgrading to Simparica Trio heartworm and flea prevention 22.1-44 lbs for complete parasite control.
Simparica Trio is safe for dogs 8 weeks and older weighing at least 2.8 lbs. However, some dogs may experience mild side effects.
⚠ Use caution in dogs with a history of seizures or neurological disorders.
⚠ Not evaluated for use in breeding, pregnant, or lactating dogs.
⚠ Keep out of reach of children and pets to prevent accidental ingestion.
Simparica Trio is a once-monthly chewable tablet that prevents heartworms, kills fleas & ticks, and treats roundworms & hookworms in dogs weighing 22.1-44.0 lbs.
It starts killing fleas within 4 hours and ticks within 8 hours after administration.
Yes, it can be given with or without food, and most dogs enjoy its tasty liver flavor.
Yes! By eliminating deer ticks (Ixodes scapularis), Simparica Trio reduces the risk of Lyme disease transmission.
If you miss a dose, administer it immediately, then continue with the regular monthly schedule. Consult your vet if unsure.
If you notice any omissions or errors in the product information on this page, please use the correction request form below.
Correction Request Form